解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:INTRODUCTION:Mesenchymal stem cells (MSCs) can differentiate into various cell types. METHODS:In this study we investigated the potential of human tonsil-derived MSCs (T-MSCs) for neuromuscular regeneration in trembler-J (Tr-J) mice, a model for Charcot-Marie-Tooth disease type 1A (CMT1A). RESULTS:T-MSCs differentiat...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25763
更新日期:2018-03-01 00:00:00
abstract:INTRODUCTION:The ability to distinguish between normal thymus, thymic hyperplasia, and thymoma should aid clinical management and decision making in patients with myasthenia gravis (MG). We sought to determine the accuracy of routine imaging in predicting thymic pathology. METHODS:We retrospectively analyzed records o...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.26096
更新日期:2018-02-09 00:00:00
abstract:INTRODUCTION:Muscle changes in patients with diabetes and lower leg pain due to chronic exertional compartment syndrome (CECS) were investigated before and after fasciotomy. METHODS:The tibialis anterior muscle was analyzed with histochemical and morphological techniques in 7 patients with diabetes and CECS before fas...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25715
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION:Few data exist on the feasibility and reliability of measuring muscular atrophy in 2 dimensions (2D) by ultrasonography (US) and elasticity with shear wave elastography (SWE) in spastic muscles. METHODS:Fourteen patients with chronic stroke took part in 2 intersession reliability experiments performed wit...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25716
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION:Duration of training to reliably measure nerve cross-sectional area with ultrasound is unknown. METHODS:A retrospective review was performed of ultrasound data, acquired and recorded by 2 examiners-an expert and either a trainee with 2 months (novice) or a trainee with 12 months (experienced) of experienc...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25980
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION:We aimed to investigate whether sonographic peripheral cross-sectional nerve area (CSA) and progranulin (PGRN), a neuritic growth factor, are related to each other and whether they interact to predict clinical and paraclinical measures in amyotrophic lateral sclerosis (ALS). METHODS:We included 55 ALS pat...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25682
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION:We quantified intraneural blood flow (INBF) in 18 patients with end-stage kidney disease (ESKD) and examined its relationship with nerve size, neuropathy severity, and nerve excitability parameters. METHODS:Sonographic measurements of the median nerve were performed at the same site before and after hemod...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25704
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION:In this study we investigated the interaction between adipose tissue-derived stem cells (ASCs) and myoblasts in co-culture experiments. METHODS:Specific inductive media were used to differentiate ASCs in vitro into a Schwann cell-like phenotype (differentiated adipose tissue-derived stem cells, or dASCs) ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25741
更新日期:2018-02-01 00:00:00
abstract:INTRODUCTION:This study was undertaken to describe a method for quantifying vibration when using a conventional tuning fork (CTF) in comparison to a Rydel-Seiffer tuning fork (RSTF) and to provide reference values. METHODS:Vibration thresholds at index finger and big toe were obtained in 281 participants. Spearman's c...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25680
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Muscle force generation involves recruitment and firing rate modulation of motor units (MUs). The control of MUs in producing multidirectional forces remains unclear. METHODS:We studied MU recruitment and firing properties, recorded from the first dorsal interosseous muscle, for 3 different directions of ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25963
更新日期:2018-01-01 00:00:00
abstract::Muscular dystrophy is defined as the progressive wasting of skeletal muscles that is caused by inherited or spontaneous genetic mutations. Next-generation sequencing has greatly improved the accuracy and speed of diagnosis for different types of muscular dystrophy. Advancements in depth of coverage, convenience, and o...
journal_title:Muscle & nerve
pub_type: 杂志文章,评审
doi:10.1002/mus.25953
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:We investigated the effects of aerobic and resistance exercise in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS:Eighteen CIDP patients treated with subcutaneous immunoglobulin performed 12 weeks of aerobic exercise and 12 weeks of resistance exercise after a run-in period...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25652
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Autosomal dominant haploinsufficiency of GATA2 causes monocytopenia and natural killer cell lymphopenia, resulting in predisposition to mycobacterial, fungal, and viral infections. METHODS:Herein we report on the clinical, serologic, electrophysiologic, and pathologic evaluations of a 29-year-old woman wi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25581
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Peripheral nerve injuries (PNI) are among the leading causes of physical disability in the United States. The majority of injuries occur in the upper extremities, and functional recovery is often limited. Robust animal models are critical first steps for developing effective therapies to restore function a...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25590
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:Previous studies have reported higher wrist ratios (WR) related to carpal tunnel syndrome (CTS) but have not assessed effect modification by obesity and may have inadequately controlled for confounders. METHODS:Baseline data of a multicenter prospective cohort study were analyzed. CTS was defined by nerve...
journal_title:Muscle & nerve
pub_type: 杂志文章,多中心研究
doi:10.1002/mus.25692
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:Cranial muscle fasciculations may be difficult to detect in amyotrophic lateral sclerosis (ALS). Ultrasound (US) detection of fasciculations in these muscles may have clinical utility. METHODS:Patients with suspected ALS were prospectively enrolled. Nerve conduction studies, needle electromyography (EMG),...
journal_title:Muscle & nerve
pub_type: 杂志文章,多中心研究
doi:10.1002/mus.25676
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:Slowly progressive, genetic neuromuscular diseases (gNMDs) often lead to important motor deficiencies and functional limitations. The Quality of Life in Genetic Neuromuscular Disease Questionnaire (QoL-gNMD) is a new health-related quality-of-life questionnaire developed for these patients. The purpose of ...
journal_title:Muscle & nerve
pub_type: 杂志文章,多中心研究
doi:10.1002/mus.25598
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to describe the therapeutic effects of immunomodulatory therapy in 3 patients with childhood autoimmune necrotizing myopathy with anti-signal recognition particle antibodies (SRP-ANM). METHODS:Before treatment, data on clinical features, muscle pathology, and thigh MRIs were obta...
journal_title:Muscle & nerve
pub_type:
doi:10.1002/mus.25575
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:This study compares the acute and chronic response of high-load resistance training (HL) to low-load resistance training with low blood flow restriction (LL-BFR) pressure. METHODS:Participants completed elbow flexion with either HL or LL-BFR or nonexercise. In the chronic study, participants in the HL and...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25626
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration leading to immobility, respiratory failure, and premature death. As chronic inflammation and stress are implicated in DMD pathology, the efficacy of an anti-inflammatory and anti-stress intervention strategy in ameliorati...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25644
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:We assessed antibodies against low-density lipoprotein receptor-related protein 4 (LRP4-Ab) in a Chinese population with myasthenia gravis (MG). METHODS:Serum samples from 116 patients and 80 controls were collected. Acetylcholine receptor antibodies(AChR-Ab) and muscle-specific receptor tyrosine kinase a...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25591
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION:Polyneuropathy signs (Neuropathy Impairment Score, NIS), neurophysiologic tests (m+7Ionis ), disability, and health scores were assessed in baseline evaluations of 100 patients entered into an oligonucleotide familial amyloidotic polyneuropathy (FAP) trial. METHODS:We assessed: (1) Proficiency of grading ...
journal_title:Muscle & nerve
pub_type: 杂志文章,多中心研究
doi:10.1002/mus.25563
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION:Hand-held dynamometry (HHD) is commonly used to measure ankle plantarflexion strength but has variable reliability measuring higher forces. Fixed HHD is suggested to improve reliability. We, therefore, compared the reliability, consistency, and accuracy of measuring plantarflexion strength. METHODS:Planta...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25576
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION:Merkel cell carcinoma is a rare cutaneous, aggressive tumor. Although it shares many neuroendocrine features with small cell lung carcinoma, it has only occasionally been reported with paraneoplastic neurological syndromes. METHODS:A healthy 67-year-old man developed acute ataxia, vertigo, and nausea. Sub...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25530
更新日期:2017-11-01 00:00:00
abstract:INTRODUCTION:In this study we noninvasively evaluated skeletal muscle mitochondrial capacity, muscle-specific endurance, and energy/fatigue feelings in persons with Friedreich ataxia (FRDA) and able-bodied controls (AB). METHODS:Forearm mitochondrial capacity was measured in FRDA (n = 16) and AB (n = 10) study partici...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25524
更新日期:2017-10-01 00:00:00
abstract:INTRODUCTION:In compressive neuropathies, large myelinated nerve fibers are generally thought to be more susceptible. In this study, we investigated small myelinated Aδ and unmyelinated C fiber function in patients with mild, moderate, and severe carpal tunnel syndrome. METHODS:Forty-four healthy controls and 81 carpa...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25592
更新日期:2017-10-01 00:00:00
abstract:INTRODUCTION:Eosinophilic fasciitis (EF) is a rare disorder that can present with muscle symptoms that mimic other neuromuscular diseases. METHODS:We report the case of a 43-year-old woman with chronic muscle aches, tightness, and stiffness with hypertrophied, well-defined muscles despite physical inactivity, and thic...
journal_title:Muscle & nerve
pub_type:
doi:10.1002/mus.25492
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:We sought to compare median nerve elasticity between leprosy patients (LPs) and healthy volunteers (HVs) using ultrasound elastography (UE). METHODS:Two radiologists independently measured the strain ratio of the median nerve/flexor digitorum superficialis muscle (MN/FDSM) of 18 LP and 18 HV using real-ti...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25510
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Mutations in the guanosine diphosphate-mannose pyrophosphorylase-B gene (GMPPB) have been identified in congenital muscular dystrophies, limb-girdle muscular dystrophy (LGMD2T), and congenital myasthenic syndromes (CMSs); overall, 41 patients have been described. METHODS:Two patients presented with a myas...
journal_title:Muscle & nerve
pub_type:
doi:10.1002/mus.25485
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:Ulnar neuropathy at the elbow (UNE) is a common peripheral compression neuropathy and, in most cases, occurs at 2 sites, the retroepicondylar groove or the cubital tunnel. With regard to a potential therapeutic approach with perineural corticosteroid injection, the aim of this study was to evaluate the dis...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25490
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:Congenital myotonic dystrophy (CDM) occurs when symptoms of myotonic dystrophy present at birth. In this study we evaluated the relationship between physical function, muscle mass, and age to provide an assessment of the disease and help prepare for therapeutic trials. METHODS:CDM participants performed t...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25482
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:Respiratory and locomotor skeletal muscle dysfunction are common findings in chronic obstructive pulmonary disease (COPD); however, the mechanisms that cause muscle impairment in COPD are unclear. Because Ca2+ signaling in excitation-contraction (E-C) coupling is important for muscle activity, we hypothesi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25466
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:In this study we examined relationships among mechanomyographic (MMG), electromyographic (EMG), and peak twitch torque (PTT) responses as well as test-retest reliability when recorded during recruitment curves in the soleus muscle. METHODS:PTT, EMG (M-wave, H-reflex), and MMG responses were recorded durin...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25432
更新日期:2017-07-01 00:00:00
abstract:INTRODUCTION:Lower limb strength has never been characterized separately for late-onset and adult myotonic dystrophy type 1 (DM1) phenotypes. METHODS:The purpose of this study was to: (1) describe and compare lower limb strength between the 2 DM1 phenotypes; and (2) compare the impairment profiles obtained from 2 asse...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25451
更新日期:2017-07-01 00:00:00
abstract:INTRODUCTION:We report preliminary findings of nerve ultrasound in patients with cerebellar ataxia neuropathy vestibular areflexia syndrome (CANVAS) who have sensory impairment due to dorsal root ganglionopathy. METHODS:The ultrasound cross-sectional area (CSA) of median and ulnar nerves of 7 CANVAS patients was compa...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25476
更新日期:2017-07-01 00:00:00
abstract:INTRODUCTION:In this study we aimed to identify prognostic factors of ulnar neuropathy at the elbow (UNE) and developed a scoring system to establish the prognosis. METHODS:We collected baseline clinical, electrophysiologic, and ultrasonographic data from 2 cohorts. The outcomes for all patients were determined on fol...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25406
更新日期:2017-05-01 00:00:00
abstract:INTRODUCTION:Chediak-Higashi syndrome (CHS) is a very rare autosomal recessive disorder (gene CHS1/LYST) characterized by partial albinism, recurrent infections, and easy bruising. Survivors develop a constellation of slowly progressive neurological manifestations. METHODS:We describe clinical, laboratory, electrophys...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25414
更新日期:2017-05-01 00:00:00
abstract:INTRODUCTION:Peripheral nerves are often exposed to mechanical stress leading to compression neuropathies. The pathophysiology underlying nerve dysfunction by chronic compression is largely unknown. METHODS:We analyzed molecular organization and fine structures at and near nodes of Ranvier in a compression neuropathy ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25273
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:Voltage-gated Kv1 potassium channel complex (VGKC) autoantibodies subtyped for leucine-rich glioma-inactivated 1 (LGI1), contactin-associated-proteinlike 2 (CASPR2), and Kv IgGs have a spectrum of neurological presentations. Painful polyneuropathy is seen in some patients, but nerve pathology descriptions ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25371
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:The ability to individualize recommendations or expectations of disease progression based on a patient's unique characteristics has merit for use in sporadic inclusion body myositis (sIBM). METHODS:Fifty-five subjects with sIBM completed a battery of strength and functional outcomes at 2 study visits. The...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.25373
更新日期:2017-04-01 00:00:00